Comer is noted for her role as 'Oksana Astankova'/'Villanelle' in the BBC America comedy spy thriller series "Killing Eve" (2018–present)...
Her other notable roles include 'Chloe Gemell' in the E4 comedy-drama series "My Mad Fat Diary" (2013–2015)…
… 'Kate Parks' in the BBC One drama series "Doctor Foster" (2015–2017), 'Ivy Moxam' in the BBC Three drama miniseries "Thirteen" (2016)…
…and as 'Elizabeth of York' in the Starz historical miniseries "The White Princess" (2017).
Comer co-starred with Ryan Reynolds in the action comedy "Free Guy" and starred with Matt Damon and Ben Affleck in Ridley Scott's "The Last Duel" (2023).