Cardellini is noted for starring roles in the teen drama “Freaks and Geeks” (1999–2000), the medical drama “ER” I2003–2009), and the thriller “Bloodline” (2015–2017), as well as for her guest role as ‘Sylvia Rosen’ on AMC's “Mad Men” (2013–2015).
Her starring role in the Netflix dark comedy series “Dead to Me” (2019–2022) earned her a nomination for a ‘Primetime Emmy Award’ for ‘Outstanding Lead Actress’.
In film, Cardellini became known for playing ‘Velma Dinkley’ in “Scooby-Doo” (2002) and its 2004 sequel. Her other credits include “Legally Blonde” (2001), “Brokeback Mountain” (2005), “Daddy's Home” (2015) and its sequel “Daddy's Home 2”.
She also plays ‘Laura Barton’ , the wife of ‘Clint’ in Marvel Television’s “Hawkeye” TV series.
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